C17orf104

Entrez Summary: N/A
UniProt Summary: Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. {ECO:0000250|UniProtKB:A2AG06}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCT251545 0.2μM R06 exp271	-2.58
Nocodazole 0.02μM R00 exp23	-1.81
Etoposide 0.3μM R05 exp199	-1.8
BS-181 20μM R08 exp461	-1.77
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.92

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell cycle switching, mitotic to meiotic cell cycle
cell cycle switching
germline cell cycle switching, mitotic to meiotic cell cycle
female meiosis I
synaptonemal complex assembly
synaptonemal complex organization
male meiosis I
positive regulation of meiotic cell cycle
female meiotic nuclear division
oocyte development
mRNA stabilization
oocyte differentiation
synapsis
male meiotic nuclear division
RNA stabilization
regulation of meiotic cell cycle
negative regulation of mRNA catabolic process
metaphase plate congression
homologous chromosome segregation
negative regulation of RNA catabolic process
chromosome organization involved in meiotic cell cycle
establishment of chromosome localization
chromosome localization
positive regulation of reproductive process
oogenesis
negative regulation of mRNA metabolic process
meiotic chromosome segregation
meiosis I
meiosis I cell cycle process
female gamete generation
spermatid development
meiotic nuclear division
spermatid differentiation
regulation of reproductive process
meiotic cell cycle process
regulation of mRNA stability
double-strand break repair
regulation of RNA stability
regulation of mRNA catabolic process
nuclear chromosome segregation