C1GALT1

Official Symbol: C1GALT1
Official Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 56913
UniProt: Q9NS00
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010].
UniProt Summary: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
All-trans-Retinoic-Acid 8μM R07 exp333	-1.78
HMS-I1 10μM R06 exp256	1.71
SB743921 0.001μM R05 exp244	1.87
Nocodazole 0.2μM R00 exp24	1.89

O-glycan processing, core 1
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
intestinal epithelial cell development
intestinal epithelial cell differentiation
columnar/cuboidal epithelial cell development
O-glycan processing
columnar/cuboidal epithelial cell differentiation
protein O-linked glycosylation
digestive tract development
digestive system development
epithelial cell development
protein glycosylation
macromolecule glycosylation
glycosylation
kidney development
renal system development
angiogenesis
urogenital system development
glycoprotein biosynthetic process
glycoprotein metabolic process
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
Golgi membrane
carbohydrate derivative biosynthetic process
tube morphogenesis
epithelial cell differentiation
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
carbohydrate derivative metabolic process
epithelium development
organonitrogen compound biosynthetic process
cell development
cellular macromolecule biosynthetic process
tissue development
macromolecule biosynthetic process