C1orf106

Gene Information

Official Symbol: INAVA
Official Name: innate immunity activator
Aliases and Previous Symbols: N/A
Entrez ID: 55765
UniProt: Q3KP66
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. {ECO:0000269|PubMed:28436939}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3451
Expression level (log2 read counts): 2.28

Expression Distribution

intestinal epithelial structure maintenance
adherens junction maintenance
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to peptidoglycan
cell junction maintenance
maintenance of gastrointestinal epithelium
response to muramyl dipeptide
cytokine production involved in immune response
reactive oxygen species biosynthetic process
nucleotide-binding oligomerization domain containing signaling pathway
epithelial structure maintenance
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
cytoplasmic pattern recognition receptor signaling pathway
positive regulation of interleukin-10 production
cellular component maintenance
positive regulation of interleukin-1 beta production
regulation of interleukin-10 production
positive regulation of interleukin-1 production
digestive system process
regulation of interleukin-1 beta production
adherens junction organization
positive regulation of interleukin-6 production
regulation of interleukin-1 production
reactive oxygen species metabolic process
digestion
positive regulation of protein ubiquitination
pattern recognition receptor signaling pathway
positive regulation of protein modification by small protein conjugation or removal
regulation of interleukin-6 production
cytokine production
activation of MAPK activity
intracellular receptor signaling pathway
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
production of molecular mediator of immune response
positive regulation of I-kappaB kinase/NF-kappaB signaling
tissue homeostasis
regulation of protein ubiquitination
cell junction organization
regulation of protein modification by small protein conjugation or removal