C3AR1

Gene Information

Official Symbol: C3AR1
Official Name: complement C3a receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 719
UniProt: Q16581
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016].
UniProt Summary: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5360
Expression level (log2 read counts): -2.69

Expression Distribution

Screen	Score
GSK-J4 1.5μM R08 exp441	-1.74
Dinaciclib 0.007μM R07 exp355	-1.7
Ribavirin 10μM R01 exp52	1.94

7tm 1
7TM GPCR Srsx

complement component C3a receptor activity
complement receptor mediated signaling pathway
positive regulation of macrophage chemotaxis
positive regulation of macrophage migration
positive regulation of neutrophil chemotaxis
positive regulation of granulocyte chemotaxis
regulation of macrophage chemotaxis
positive regulation of vascular endothelial growth factor production
positive regulation of neutrophil migration
regulation of neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
regulation of vascular endothelial growth factor production
regulation of neutrophil migration
regulation of macrophage migration
regulation of granulocyte chemotaxis
regulation of mononuclear cell migration
azurophil granule membrane
positive regulation of leukocyte chemotaxis
specific granule membrane
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of leukocyte chemotaxis
regulation of complement activation
positive regulation of leukocyte migration
positive regulation of chemotaxis
regulation of humoral immune response
positive regulation of angiogenesis
positive regulation of vasculature development
regulation of leukocyte migration
regulation of chemotaxis
positive regulation of cytosolic calcium ion concentration
regulation of angiogenesis
regulation of vasculature development
regulation of cytosolic calcium ion concentration
blood circulation
circulatory system process
cellular calcium ion homeostasis
immune response-activating cell surface receptor signaling pathway
calcium ion homeostasis
positive regulation of cytokine production
regulation of immune effector process