CABIN1

Entrez Summary: Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011].
UniProt Summary: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome binding
protein phosphatase inhibitor activity
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
aggresome
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
nucleosome assembly
regulation of phosphoprotein phosphatase activity
chromatin assembly
regulation of protein dephosphorylation
chromatin assembly or disassembly
nucleosome organization
regulation of phosphatase activity
DNA packaging
protein-DNA complex assembly
regulation of dephosphorylation
protein-DNA complex subunit organization
DNA conformation change
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
chromatin organization
negative regulation of catalytic activity
cellular protein-containing complex assembly
negative regulation of cellular protein metabolic process
chromosome organization
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
protein-containing complex assembly
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
protein-containing complex subunit organization