CARD18

Gene Information

Official Symbol: CARD18
Official Name: caspase recruitment domain family member 18
Aliases and Previous Symbols: N/A
Entrez ID: 59082
UniProt: P57730
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269|PubMed:11051551}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18435
Expression level (log2 read counts): -4.27

Expression Distribution

caspase binding
zymogen inhibition
inhibition of cysteine-type endopeptidase activity
negative regulation of interleukin-1 beta secretion
CARD domain binding
negative regulation of interleukin-1 secretion
negative regulation of interleukin-1 beta production
cysteine-type endopeptidase inhibitor activity
negative regulation of protein processing
negative regulation of protein maturation
negative regulation of interleukin-1 production
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
regulation of protein processing
negative regulation of cytokine secretion
regulation of protein maturation
regulation of interleukin-1 beta production
negative regulation of cysteine-type endopeptidase activity
regulation of interleukin-1 production
negative regulation of protein binding
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of binding
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
regulation of protein binding
negative regulation of secretion
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of cytokine production
negative regulation of proteolysis
regulation of binding
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of protein secretion
negative regulation of transport