CBX8

Entrez Summary: N/A
UniProt Summary: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-protein transferase activator activity
PRC1 complex
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
heterochromatin
PcG protein complex
regulation of collagen biosynthetic process
histone ubiquitination
regulation of collagen metabolic process
single-stranded RNA binding
methylated histone binding
positive regulation of DNA repair
cellular response to hydrogen peroxide
positive regulation of response to DNA damage stimulus
cellular response to antibiotic
response to hydrogen peroxide
regulation of DNA repair
cellular response to reactive oxygen species
positive regulation of DNA metabolic process
response to reactive oxygen species
cellular response to toxic substance
regulation of response to DNA damage stimulus
nuclear chromatin
cellular response to oxidative stress
response to antibiotic
regulation of DNA metabolic process
histone modification
covalent chromatin modification
response to oxidative stress
cellular response to drug
response to toxic substance
response to inorganic substance
protein ubiquitination
chromatin organization
regulation of cellular response to stress
protein modification by small protein conjugation
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
protein modification by small protein conjugation or removal
response to drug