CD33

Gene Information

Official Symbol: CD33
Official Name: CD33 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 945
UniProt: P20138
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:11320212}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12195
Expression level (log2 read counts): 3.52

Expression Distribution

Screen	Score
Trimetrexate 0.03μM R08 exp535	-1.82
UM0011500 5μM R05 exp245	2.01

ig
V-set

negative regulation of monocyte activation
positive regulation of protein tyrosine phosphatase activity
regulation of protein tyrosine phosphatase activity
immune response-inhibiting signal transduction
sialic acid binding
negative regulation of interleukin-8 production
positive regulation of phosphoprotein phosphatase activity
negative regulation of interleukin-1 beta production
negative regulation of interleukin-1 production
positive regulation of phosphatase activity
positive regulation of protein dephosphorylation
positive regulation of dephosphorylation
negative regulation of tumor necrosis factor production
negative regulation of calcium ion transport
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of interleukin-8 production
tertiary granule membrane
regulation of interleukin-1 beta production
protein phosphatase binding
specific granule membrane
regulation of interleukin-1 production
peroxisome
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
negative regulation of ion transport
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
carbohydrate binding
regulation of phosphatase activity
signaling receptor activity
regulation of dephosphorylation
regulation of calcium ion transport
positive regulation of protein secretion
negative regulation of cytokine production
positive regulation of peptide secretion
regulation of metal ion transport
external side of plasma membrane
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion