CDC16

Entrez Summary: N/A
UniProt Summary: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.17
Tozasertib 0.1μM R07 exp414	-1.93
GSK2606414 1μM R05 exp236	-1.82
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.78
Clomiphene 4.4μM R02 exp68	-1.76
Etoposide 0.3μM R05 exp199	1.73
VE-822 0.04μM R06 exp300	1.76
L-BMAA 500 to 750μM on day4 R04 exp185	1.93

Global Fraction of Cell Lines Where Essential: 737/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

TPR 1
Apc3

anaphase-promoting complex
protein K11-linked ubiquitination
spindle microtubule
anaphase-promoting complex-dependent catabolic process
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
centrosome
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of mitotic cell cycle
protein catabolic process
protein ubiquitination
regulation of cell cycle process
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of cell cycle
proteolysis
cell cycle
organic substance catabolic process
cellular catabolic process