CDHR2

Entrez Summary: N/A
UniProt Summary: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Fluvastatin 2.2μM R06 exp282	-1.84
Caffeine 2600μM R08 exp463	-1.7

negative regulation of cell growth involved in contact inhibition
intermicrovillar adhesion
brush border assembly
spanning component of plasma membrane
regulation of microvillus length
contact inhibition
regulation of microvillus organization
regulation of cell projection size
microvillus membrane
cell-cell adhesion mediated by cadherin
brush border
brush border membrane
cell adhesion molecule binding
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell growth
negative regulation of growth
cell-cell adhesion via plasma-membrane adhesion molecules
apical plasma membrane
regulation of cellular component size
regulation of cell growth
cell-cell adhesion
regulation of anatomical structure size
cell junction
regulation of growth
epithelial cell differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
calcium ion binding
cell adhesion
biological adhesion
epithelium development
tissue development