CDK5RAP3

Gene Information

Official Symbol: CDK5RAP3
Official Name: CDK5 regulatory subunit associated protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 80279
UniProt: Q96JB5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). {ECO:0000269|PubMed:12054757, ECO:0000269|PubMed:12737517, ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:17785205, ECO:0000269|PubMed:19223857, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:23478299}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4080
Expression level (log2 read counts): 7.35

Expression Distribution

Screen	Score
LB-100 4.1μM R02 exp72	-1.96
Golgicide-A 4μM R03 exp122	-1.7
Palbociclib 1μM R07 exp382	1.95

protein ufmylation
MDM2/MDM4 family protein binding
negative regulation of protein kinase activity by regulation of protein phosphorylation
mitotic G2 DNA damage checkpoint
positive regulation of signal transduction by p53 class mediator
mitogen-activated protein kinase binding
ubiquitin-like protein ligase binding
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
mitotic G2/M transition checkpoint
NF-kappaB binding
G2 DNA damage checkpoint
cyclin binding
execution phase of apoptosis
negative regulation of MAP kinase activity
positive regulation of protein localization to nucleus
negative regulation of NF-kappaB transcription factor activity
negative regulation of cellular protein catabolic process
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
positive regulation of ubiquitin-dependent protein catabolic process
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle G2/M phase transition
regulation of cyclin-dependent protein kinase activity
mitotic DNA integrity checkpoint
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
regulation of protein localization to nucleus
positive regulation of proteolysis involved in cellular protein catabolic process
cellular response to unfolded protein
DNA damage checkpoint
negative regulation of protein serine/threonine kinase activity
negative regulation of protein catabolic process
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
DNA integrity checkpoint
cellular response to topologically incorrect protein
regulation of ubiquitin-dependent protein catabolic process
mitotic cell cycle checkpoint
negative regulation of DNA-binding transcription factor activity