CDKN1C

Gene Information

Official Symbol: CDKN1C
Official Name: cyclin dependent kinase inhibitor 1C
Aliases and Previous Symbols: N/A
Entrez ID: 1028
UniProt: P49918
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
UniProt Summary: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13245
Expression level (log2 read counts): 1.15

Expression Distribution

Screen	Score
B02 10μM R08 exp453	1.71
Bisphenol F 50μM R08 exp457	1.92

regulation of lens fiber cell differentiation
cyclin-dependent protein serine/threonine kinase inhibitor activity
regulation of exit from mitosis
uterus development
genetic imprinting
adrenal gland development
embryonic placenta morphogenesis
protein kinase inhibitor activity
positive regulation of cellular response to transforming growth factor beta stimulus
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cyclin-dependent protein kinase activity
neuron maturation
multicellular organism growth
embryonic placenta development
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
endocrine system development
negative regulation of epithelial cell proliferation
negative regulation of protein serine/threonine kinase activity
anatomical structure maturation
regulation of epithelial cell differentiation
digestive system development
cell cycle arrest
placenta development
cell maturation
regulation of mitotic nuclear division
regulation of nuclear division
myeloid cell differentiation
negative regulation of protein kinase activity
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
developmental maturation
negative regulation of kinase activity
protein-containing complex binding
kidney development
regulation of cellular response to growth factor stimulus
negative regulation of transferase activity