CDKN2C

Gene Information

Official Symbol: CDKN2C
Official Name: cyclin dependent kinase inhibitor 2C
Aliases and Previous Symbols: N/A
Entrez ID: 1031
UniProt: P42773
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13951
Expression level (log2 read counts): 5.77

Expression Distribution

Ank 2
Ank

cyclin-dependent protein serine/threonine kinase inhibitor activity
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
oligodendrocyte differentiation
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
negative regulation of protein serine/threonine kinase activity
cell cycle arrest
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
glial cell differentiation
negative regulation of cell growth
negative regulation of mitotic cell cycle phase transition
gliogenesis
negative regulation of protein kinase activity
negative regulation of cell cycle phase transition
negative regulation of growth
negative regulation of kinase activity
mitotic cell cycle phase transition
negative regulation of transferase activity
cell cycle phase transition
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
negative regulation of protein phosphorylation
regulation of mitotic cell cycle phase transition
regulation of cell growth
negative regulation of phosphorylation
regulation of cell cycle phase transition
protein kinase binding
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
mitotic cell cycle process
regulation of mitotic cell cycle