CDON

Entrez Summary: This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011].
UniProt Summary: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.87
Golgicide-A 4μM R03 exp122	1.95

skeletal muscle satellite cell differentiation
embryonic body morphogenesis
embryonic retina morphogenesis in camera-type eye
regulation of protein heterodimerization activity
myoblast fusion
positive regulation of myoblast differentiation
positive regulation of skeletal muscle tissue development
syncytium formation by plasma membrane fusion
cell-cell fusion
syncytium formation
body morphogenesis
regulation of skeletal muscle tissue development
retina morphogenesis in camera-type eye
skeletal muscle cell differentiation
positive regulation of neural precursor cell proliferation
regulation of myoblast differentiation
myotube differentiation
positive regulation of striated muscle tissue development
positive regulation of muscle organ development
positive regulation of muscle tissue development
positive regulation of small GTPase mediated signal transduction
smoothened signaling pathway
lens development in camera-type eye
positive regulation of muscle cell differentiation
cell fate specification
regulation of neural precursor cell proliferation
camera-type eye morphogenesis
cerebral cortex development
skeletal muscle tissue development
regulation of striated muscle tissue development
skeletal muscle organ development
regulation of muscle tissue development
regulation of muscle organ development
retina development in camera-type eye
eye morphogenesis
regulation of muscle cell differentiation
pallium development
striated muscle cell differentiation
anterior/posterior pattern specification
regulation of protein binding