CERS5

Entrez Summary: N/A
UniProt Summary: Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Geldanamycin 0.01μM R05 exp235	1.79
L-74142 5μM R03 exp131	1.83

TRAM LAG1 CLN8
Homeobox

sphingosine N-acyltransferase activity
ceramide biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
nuclear membrane
amide biosynthetic process
lipid biosynthetic process
cellular amide metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
lipid metabolic process
organonitrogen compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process