CHST7

Entrez Summary: This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013].
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

chondroitin 6-sulfotransferase activity
N-acetylglucosamine 6-O-sulfotransferase activity
N-acetylglucosamine metabolic process
glucosamine-containing compound metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
amino sugar metabolic process
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
trans-Golgi network
sulfur compound biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process