CLEC12A
Gene Information
- Official Symbol: CLEC12A
- Official Name: C-type lectin domain family 12 member A
- Aliases and Previous Symbols: N/A
- Entrez ID: 160364
- UniProt: Q5QGZ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011].
- UniProt Summary: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17520
- Expression level (log2 read counts): 5.37
CLEC12A Expression in NALM6 Cells: 5.37
