CLEC4D

Gene Information

Official Symbol: CLEC4D
Official Name: C-type lectin domain family 4 member D
Aliases and Previous Symbols: N/A
Entrez ID: 338339
UniProt: Q8WXI8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. {ECO:0000269|PubMed:14971047}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8822
Expression level (log2 read counts): -5.28

Expression Distribution

positive regulation of myeloid dendritic cell activation
regulation of myeloid dendritic cell activation
T cell differentiation involved in immune response
ficolin-1-rich granule membrane
T cell activation involved in immune response
tertiary granule membrane
specific granule membrane
immunoglobulin receptor binding
lymphocyte activation involved in immune response
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
T cell differentiation
Fc-gamma receptor signaling pathway
carbohydrate binding
innate immune response-activating signal transduction
T cell activation
lymphocyte differentiation
Fc receptor signaling pathway
activation of innate immune response
defense response to bacterium
leukocyte differentiation
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
positive regulation of leukocyte activation
positive regulation of cell activation
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
positive regulation of multi-organism process
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of response to biotic stimulus