CNTFR

Entrez Summary: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011].
UniProt Summary: Binds to CNTF. The alpha subunit provides the receptor specificity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CNTFR-CLCF1 complex
interleukin-27 receptor binding
ciliary neurotrophic factor receptor complex
ciliary neurotrophic factor receptor activity
ciliary neurotrophic factor-mediated signaling pathway
brainstem development
suckling behavior
cytokine binding
cytokine receptor activity
extrinsic component of membrane
multi-organism behavior
feeding behavior
anchored component of membrane
skeletal muscle organ development
negative regulation of neuron apoptotic process
receptor complex
regulation of neuron apoptotic process
negative regulation of neuron death
sex differentiation
muscle organ development
regulation of neuron death
apical plasma membrane
signaling receptor binding
external side of plasma membrane
muscle structure development
behavior
developmental process involved in reproduction
cytokine-mediated signaling pathway
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
negative regulation of cell death
cellular response to cytokine stimulus
response to cytokine
reproductive process
reproduction
regulation of apoptotic process
regulation of programmed cell death
regulation of cell population proliferation
regulation of cell death