CNTLN

Entrez Summary: N/A
UniProt Summary: Required for centrosome cohesion and recruitment of CEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.8
Docosahexaenoic-acid 50μM R07 exp356	1.88
Lenalidomide 20μM R07 exp375	1.94

centriole-centriole cohesion
protein binding, bridging
centrosome cycle
microtubule organizing center organization
centriole
protein domain specific binding
protein kinase binding
microtubule cytoskeleton organization
centrosome
microtubule-based process
protein localization to organelle
cell cycle process
cytoskeleton organization
cell cycle
cellular protein localization
cellular macromolecule localization