COX4I2
Gene Information
- Official Symbol: COX4I2
- Official Name: cytochrome c oxidase subunit 4I2
- Aliases and Previous Symbols: N/A
- Entrez ID: 84701
- UniProt: Q96KJ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008].
- UniProt Summary: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3276
- Expression level (log2 read counts): -7.68
COX4I2 Expression in NALM6 Cells: -7.68
