CRAT

Entrez Summary: N/A
UniProt Summary: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.02μM R00 exp23	-1.85
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.8

carnitine O-acetyltransferase activity
carnitine metabolic process, CoA-linked
carnitine metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
amino-acid betaine metabolic process
peroxisomal matrix
fatty acid beta-oxidation
protein targeting to peroxisome
protein localization to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
small molecule catabolic process
monocarboxylic acid metabolic process
protein localization to organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
intracellular protein transport
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
lipid metabolic process
mitochondrion