CRLF1

Entrez Summary: This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009].
UniProt Summary: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CRLF-CLCF1 complex
negative regulation of motor neuron apoptotic process
ciliary neurotrophic factor receptor binding
regulation of motor neuron apoptotic process
interleukin-27-mediated signaling pathway
cytokine binding
cytokine receptor activity
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
positive regulation of receptor signaling pathway via STAT
mesonephros development
kidney epithelium development
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
negative regulation of neuron apoptotic process
cytokine activity
positive regulation of peptidyl-tyrosine phosphorylation
receptor complex
negative regulation of neuron death
regulation of neuron apoptotic process
regulation of peptidyl-tyrosine phosphorylation
kidney development
renal system development
regulation of neuron death
urogenital system development
external side of plasma membrane
protein heterodimerization activity
cytokine-mediated signaling pathway
tube development
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
negative regulation of cell death
cellular response to cytokine stimulus
positive regulation of protein phosphorylation
positive regulation of phosphorylation