CRX

Gene Information

Official Symbol: CRX
Official Name: cone-rod homeobox
Aliases and Previous Symbols: N/A
Entrez ID: 1406
UniProt: O43186
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269|PubMed:10625658}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14174
Expression level (log2 read counts): 4.06

Expression Distribution

Homeobox
TF Otx

positive regulation of photoreceptor cell differentiation
regulation of photoreceptor cell differentiation
leucine zipper domain binding
nuclear hormone receptor binding
circadian rhythm
visual perception
sensory perception of light stimulus
rhythmic process
positive regulation of neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of neurogenesis
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
animal organ morphogenesis
positive regulation of cell differentiation
sensory perception
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
nervous system process
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of multicellular organismal process
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
system process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process