CSNK1G2

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15342122, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Resveratrol 16μM R03 exp147	-1.89
Vemurafenib 6.6μM R08 exp434	1.71

peptidyl-threonine phosphorylation
peptidyl-threonine modification
sphingolipid biosynthetic process
membrane lipid biosynthetic process
positive regulation of canonical Wnt signaling pathway
sphingolipid metabolic process
peptidyl-serine phosphorylation
positive regulation of Wnt signaling pathway
protein autophosphorylation
peptidyl-serine modification
membrane lipid metabolic process
regulation of canonical Wnt signaling pathway
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
protein serine/threonine kinase activity
cell surface receptor signaling pathway involved in cell-cell signaling
endocytosis
lipid biosynthetic process
import into cell
peptidyl-amino acid modification
cellular lipid metabolic process
protein phosphorylation
cell-cell signaling
lipid metabolic process
phosphorylation
organonitrogen compound biosynthetic process
ATP binding
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
vesicle-mediated transport
membrane