CSTF1

Entrez Summary: N/A
UniProt Summary: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 568/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	24/28
bone	19/25
breast	23/33
central nervous system	50/56
cervix	2/4
colorectal	12/17
esophagus	9/13
fibroblast	1/1
gastric	10/15
kidney	19/21
liver	16/20
lung	60/75
lymphocyte	14/14
ovary	19/26
pancreas	15/24
peripheral nervous system	15/16
plasma cell	7/15
prostate	1/1
skin	20/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	14/22
urinary tract	21/29
uterus	5/5

Expression Distribution

Screen	Score
Monensin 0.3μM R08 exp507	-2.1
GSK626616 14μM R08 exp485	-1.85

mRNA cleavage stimulating factor complex
termination of RNA polymerase II transcription
DNA-templated transcription, termination
mRNA 3-end processing
RNA 3-end processing
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression