CTNND2

Entrez Summary: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dendritic spine morphogenesis
dendritic spine development
dendritic spine organization
neuron projection organization
dendrite morphogenesis
beta-catenin binding
postsynapse organization
dendrite development
cell-cell adherens junction
cell-cell junction assembly
perikaryon
cell-cell junction organization
cell junction assembly
cell-cell junction
cell junction organization
postsynaptic density
synapse organization
regulation of canonical Wnt signaling pathway
cadherin binding
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
dendrite
cell surface receptor signaling pathway involved in cell-cell signaling
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell-cell adhesion
cell part morphogenesis
cell morphogenesis involved in differentiation
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
cell adhesion
biological adhesion
neuron differentiation
cell-cell signaling
plasma membrane bounded cell projection organization