CTSA

Entrez Summary: This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015].
UniProt Summary: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. {ECO:0000269|PubMed:1907282}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lumenal side of lysosomal membrane
negative regulation of chaperone-mediated autophagy
serine-type carboxypeptidase activity
regulation of chaperone-mediated autophagy
carboxypeptidase activity
enzyme activator activity
glycosphingolipid metabolic process
negative regulation of autophagy
azurophil granule lumen
lysosomal lumen
glycolipid metabolic process
liposaccharide metabolic process
negative regulation of protein catabolic process
sphingolipid metabolic process
membrane lipid metabolic process
lysosome
negative regulation of cellular catabolic process
regulation of protein stability
negative regulation of catabolic process
regulation of autophagy
regulation of protein catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
leukocyte activation involved in immune response
cell activation involved in immune response
protein catabolic process
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity
exocytosis
regulation of cellular catabolic process