CYP2E1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].
UniProt Summary: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

benzene metabolic process
carbon tetrachloride metabolic process
4-nitrophenol metabolic process
4-nitrophenol 2-monooxygenase activity
halogenated hydrocarbon metabolic process
response to ozone
monoterpenoid metabolic process
lipid hydroxylation
intrinsic component of endoplasmic reticulum membrane
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
arachidonic acid epoxygenase activity
epoxygenase P450 pathway
benzene-containing compound metabolic process
exogenous drug catabolic process
long-chain fatty acid biosynthetic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
monooxygenase activity
oxygen binding
steroid hydroxylase activity
Hsp90 protein binding
Hsp70 protein binding
arachidonic acid metabolic process
triglyceride metabolic process
phenol-containing compound metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
oxidoreductase activity
terpenoid metabolic process
response to ethanol
xenobiotic metabolic process
iron ion binding
isoprenoid metabolic process
heme binding
drug catabolic process
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process