CYP46A1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Senexin-A 25μM R07 exp400	1.76
CR131-b 0.005μM R08 exp474	1.93

cholesterol 24-hydroxylase activity
progesterone metabolic process
cholesterol catabolic process
sterol catabolic process
bile acid biosynthetic process
steroid catabolic process
C21-steroid hormone metabolic process
steroid hydroxylase activity
bile acid metabolic process
regulation of long-term synaptic potentiation
alcohol catabolic process
cellular ketone metabolic process
organic hydroxy compound catabolic process
postsynapse
presynapse
cholesterol metabolic process
cellular hormone metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
xenobiotic metabolic process
iron ion binding
sterol metabolic process
heme binding
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
cellular response to xenobiotic stimulus
regulation of synaptic plasticity
hormone metabolic process
steroid metabolic process
lipid catabolic process
response to xenobiotic stimulus
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
dendrite
small molecule catabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic hydroxy compound metabolic process
organic cyclic compound catabolic process