DAP

Gene Information

Official Symbol: DAP
Official Name: death associated protein
Aliases and Previous Symbols: N/A
Entrez ID: 1611
UniProt: P51397
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
UniProt Summary: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. {ECO:0000269|PubMed:20537536}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12197
Expression level (log2 read counts): 5.84

Expression Distribution

Screen	Score
Cidofovir 10μM R07 exp345	1.85
Hippuristanol 0.12μM R08 exp488	1.97
Clomiphene 4.4μM R02 exp68	2.54

death domain binding
cellular response to amino acid starvation
response to amino acid starvation
negative regulation of NF-kappaB transcription factor activity
negative regulation of autophagy
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to starvation
positive regulation of cysteine-type endopeptidase activity
negative regulation of DNA-binding transcription factor activity
positive regulation of endopeptidase activity
positive regulation of peptidase activity
response to starvation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to nutrient levels
regulation of cysteine-type endopeptidase activity
negative regulation of cellular catabolic process
process utilizing autophagic mechanism
autophagy
cellular response to extracellular stimulus
apoptotic signaling pathway
negative regulation of catabolic process
regulation of autophagy
cellular response to external stimulus
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of DNA-binding transcription factor activity
regulation of peptidase activity
response to nutrient levels
response to extracellular stimulus
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
regulation of cellular catabolic process
apoptotic process
regulation of catabolic process
programmed cell death
cell death