DBN1
Gene Information
- Official Symbol: DBN1
- Official Name: drebrin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1627
- UniProt: Q16643
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}.
Pfam Domains GO Terms
Pfam Domains
| Cofilin ADF |
GO Terms
| cell communication by chemical coupling |
| positive regulation of receptor localization to synapse |
| site of polarized growth |
| positive regulation of protein localization to synapse |
| positive regulation of synaptic plasticity |
| profilin binding |
| postsynaptic actin cytoskeleton organization |
| actomyosin |
| postsynaptic cytoskeleton organization |
| gap junction |
| regulation of receptor localization to synapse |
| postsynaptic cytosol |
| cell communication by electrical coupling |
| cortical cytoskeleton |
| positive regulation of dendritic spine morphogenesis |
| cytoplasmic sequestering of protein |
| regulation of protein localization to synapse |
| positive regulation of dendrite morphogenesis |
| regulation of dendritic spine morphogenesis |
| positive regulation of axon extension |
| positive regulation of dendritic spine development |
| cortical actin cytoskeleton |
| regulation of neuronal synaptic plasticity |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| neural precursor cell proliferation |
| maintenance of protein location in cell |
| actin filament |
| positive regulation of axonogenesis |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| maintenance of location in cell |
| regulation of axon extension |
| regulation of postsynapse organization |
| maintenance of protein location |
| regulation of extent of cell growth |
| growth cone |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| maintenance of location |
| regulation of actin filament polymerization |
| positive regulation of developmental growth |
| lamellipodium |
| regulation of cell size |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of axonogenesis |
| regulation of synaptic plasticity |
| postsynaptic membrane |
| actin filament binding |
| actin cytoskeleton |
| regulation of synapse organization |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| actin filament organization |
| postsynaptic density |
| positive regulation of growth |
| regulation of actin filament organization |
| actin binding |
| synapse organization |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| cadherin binding |
| regulation of developmental growth |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| positive regulation of neuron differentiation |
| regulation of cellular component size |
| in utero embryonic development |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| regulation of cell growth |
| dendrite |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| cell part morphogenesis |
| regulation of anatomical structure size |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cell population proliferation |
| actin filament-based process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| embryo development |
| neuron differentiation |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| generation of neurons |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 5-Azacytidine 2μM R07 exp330 | -1.88 |
| Thimerosal 0.85μM R08 exp529 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9514
- Expression level (log2 read counts): 7.82
Expression Distribution
DBN1 Expression in NALM6 Cells: 7.82
