DDA1

Entrez Summary: N/A
UniProt Summary: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins. {ECO:0000269|PubMed:17452440}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 7μM R08 exp436	-2.24
GSK-J4 1μM R07 exp362	-2.04
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.01
Hippuristanol 0.12μM R08 exp488	-1.87
GSK626616 14μM R08 exp485	-1.75
BML-284 0.09μM R08 exp460	1.88

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cul4-RING E3 ubiquitin ligase complex
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
positive regulation of proteolysis
post-translational protein modification
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
regulation of proteolysis
regulation of cellular catabolic process
regulation of catabolic process
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process