DMTN

Gene Information

Official Symbol: DMTN
Official Name: dematin actin binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 2039
UniProt: Q08495
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12465
Expression level (log2 read counts): -5.01

Expression Distribution

protein secretion by platelet
positive regulation of platelet aggregation
calcium-mediated signaling using extracellular calcium source
positive regulation of platelet activation
negative regulation of protein targeting to membrane
positive regulation of homotypic cell-cell adhesion
positive regulation of integrin-mediated signaling pathway
spectrin-associated cytoskeleton
actin filament reorganization
platelet dense tubular network membrane
cell projection membrane
positive regulation of fibroblast migration
negative regulation of substrate adhesion-dependent cell spreading
regulation of integrin-mediated signaling pathway
regulation of platelet aggregation
negative regulation of peptidyl-threonine phosphorylation
negative regulation of focal adhesion assembly
cortical cytoskeleton
negative regulation of adherens junction organization
calcium-mediated signaling using intracellular calcium source
negative regulation of cell junction assembly
regulation of homotypic cell-cell adhesion
positive regulation of hemostasis
positive regulation of blood coagulation
negative regulation of peptidyl-serine phosphorylation
positive regulation of coagulation
spectrin binding
regulation of lamellipodium assembly
negative regulation of protein localization to membrane
regulation of fibroblast migration
regulation of platelet activation
erythrocyte development
actin filament capping
lamellipodium assembly
negative regulation of actin filament depolymerization
regulation of protein targeting to membrane
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of cell-matrix adhesion
negative regulation of intracellular protein transport
lamellipodium organization