DNASE1L2

Entrez Summary: N/A
UniProt Summary: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. {ECO:0000269|PubMed:16902420}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

corneocyte development
deoxyribonuclease I activity
deoxyribonuclease activity
keratinocyte development
DNA catabolic process, endonucleolytic
DNA catabolic process
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
molting cycle
hair cycle
epithelial cell development
keratinocyte differentiation
nucleic acid phosphodiester bond hydrolysis
epidermal cell differentiation
nucleobase-containing compound catabolic process
skin development
epidermis development
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
epithelial cell differentiation
calcium ion binding
DNA metabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
epithelium development
DNA binding
cell development
tissue development
organic substance catabolic process
cellular catabolic process
extracellular region