DOCK10

Entrez Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014].
UniProt Summary: Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

marginal zone B cell differentiation
mature B cell differentiation involved in immune response
dendritic spine morphogenesis
mature B cell differentiation
B cell homeostasis
dendritic spine development
dendritic spine organization
neuron projection organization
B cell activation involved in immune response
lymphocyte homeostasis
dendrite morphogenesis
leukocyte homeostasis
postsynapse organization
guanyl-nucleotide exchange factor activity
dendrite development
B cell differentiation
lymphocyte activation involved in immune response
dendritic spine
B cell activation
homeostasis of number of cells
lymphocyte differentiation
synapse organization
small GTPase mediated signal transduction
leukocyte differentiation
lymphocyte activation
positive regulation of GTPase activity
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
regulation of GTPase activity
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
hemopoiesis
cell morphogenesis involved in differentiation
hematopoietic or lymphoid organ development
leukocyte activation involved in immune response
cell activation involved in immune response
immune system development
neuron projection development
cell morphogenesis