DPY19L2

Entrez Summary: The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011].
UniProt Summary: Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation. {ECO:0000250, ECO:0000269|PubMed:21397063, ECO:0000269|PubMed:21397064}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 1μM R01 exp46	-1.87
Q15 2.7μM R02 exp79	-1.86
VHL-ligand-1 20μM R07 exp421	-1.75
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.78
MK2206 4μM R08 exp504	1.78
All-trans-Retinoic-Acid 8μM R07 exp333	2.11

Global Fraction of Cell Lines Where Essential: 15/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan
protein C-linked glycosylation via tryptophan
peptidyl-tryptophan modification
protein C-linked glycosylation
mannosyltransferase activity
protein mannosylation
mannosylation
nuclear inner membrane
spermatid development
spermatid differentiation
germ cell development
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
cellular process involved in reproduction in multicellular organism
glycoprotein metabolic process
spermatogenesis
male gamete generation
carbohydrate derivative biosynthetic process
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
multi-organism reproductive process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
reproductive process
reproduction
cell development
cellular macromolecule biosynthetic process
macromolecule biosynthetic process