DYNC1I1

Entrez Summary: N/A
UniProt Summary: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-1.83
Lead acetate 990μM R08 exp496	-1.75
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.76
EPZ-5676 30μM R05 exp233	1.91
Pifithrin-alpha 20μM R07 exp390	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Dynein IC2
WD40

dynein heavy chain binding
cytoplasmic dynein complex
dynein light chain binding
ATP-dependent microtubule motor activity, plus-end-directed
spectrin binding
vesicle transport along microtubule
motor activity
vesicle cytoskeletal trafficking
microtubule motor activity
cytoplasmic ribonucleoprotein granule
organelle transport along microtubule
kinetochore
condensed chromosome kinetochore
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
recycling endosome
spindle pole
vesicle
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
microtubule-based transport
antigen processing and presentation of exogenous antigen
vesicle localization
antigen processing and presentation of peptide antigen
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
microtubule binding
microtubule-based movement
microtubule
establishment of organelle localization
Golgi vesicle transport
organelle localization
microtubule-based process
perinuclear region of cytoplasm
intracellular transport
movement of cell or subcellular component
establishment of localization in cell