EDEM1

Gene Information

Official Symbol: EDEM1
Official Name: ER degradation enhancing alpha-mannosidase like protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9695
UniProt: Q92611
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. {ECO:0000269|PubMed:12610306, ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25092655}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8787
Expression level (log2 read counts): 8.49

Expression Distribution

trimming of terminal mannose on C branch
positive regulation of retrograde protein transport, ER to cytosol
protein deglycosylation involved in glycoprotein catabolic process
ubiquitin-dependent glycoprotein ERAD pathway
mannose trimming involved in glycoprotein ERAD pathway
response to glycoprotein
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
regulation of retrograde protein transport, ER to cytosol
positive regulation of protein exit from endoplasmic reticulum
positive regulation of ERAD pathway
endoplasmic reticulum mannose trimming
protein alpha-1,2-demannosylation
protein demannosylation
glycoprotein catabolic process
endoplasmic reticulum quality control compartment
regulation of protein exit from endoplasmic reticulum
misfolded protein binding
regulation of ERAD pathway
protein deglycosylation
positive regulation of response to endoplasmic reticulum stress
aggresome
IRE1-mediated unfolded protein response
ubiquitin-dependent ERAD pathway
regulation of response to endoplasmic reticulum stress
ERAD pathway
positive regulation of proteasomal protein catabolic process
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
positive regulation of proteolysis involved in cellular protein catabolic process
cellular response to unfolded protein
positive regulation of cellular protein catabolic process
cellular response to topologically incorrect protein
positive regulation of intracellular protein transport
response to unfolded protein
regulation of proteasomal protein catabolic process
response to topologically incorrect protein
carbohydrate derivative catabolic process
positive regulation of intracellular transport
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process