EDEM2
Gene Information
- Official Symbol: EDEM2
- Official Name: ER degradation enhancing alpha-mannosidase like protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55741
- UniProt: Q9BV94
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Glyco hydro 47 |
GO Terms
| trimming of terminal mannose on B branch |
| trimming of second mannose on A branch |
| trimming of first mannose on A branch |
| trimming of terminal mannose on C branch |
| positive regulation of retrograde protein transport, ER to cytosol |
| ubiquitin-dependent glycoprotein ERAD pathway |
| protein deglycosylation involved in glycoprotein catabolic process |
| mannose trimming involved in glycoprotein ERAD pathway |
| response to glycoprotein |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| regulation of retrograde protein transport, ER to cytosol |
| positive regulation of protein exit from endoplasmic reticulum |
| positive regulation of ERAD pathway |
| endoplasmic reticulum mannose trimming |
| protein alpha-1,2-demannosylation |
| protein demannosylation |
| glycoprotein catabolic process |
| endoplasmic reticulum quality control compartment |
| regulation of protein exit from endoplasmic reticulum |
| regulation of ERAD pathway |
| protein deglycosylation |
| positive regulation of response to endoplasmic reticulum stress |
| ubiquitin-dependent ERAD pathway |
| regulation of response to endoplasmic reticulum stress |
| ERAD pathway |
| positive regulation of proteasomal protein catabolic process |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of cellular protein catabolic process |
| positive regulation of intracellular protein transport |
| response to unfolded protein |
| regulation of proteasomal protein catabolic process |
| response to topologically incorrect protein |
| carbohydrate derivative catabolic process |
| positive regulation of intracellular transport |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| regulation of intracellular protein transport |
| regulation of cellular protein catabolic process |
| response to endoplasmic reticulum stress |
| endoplasmic reticulum lumen |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| positive regulation of cellular protein localization |
| proteasomal protein catabolic process |
| regulation of intracellular transport |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| glycoprotein metabolic process |
| positive regulation of protein transport |
| positive regulation of catabolic process |
| positive regulation of establishment of protein localization |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of cellular protein localization |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| regulation of protein transport |
| calcium ion binding |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of cellular catabolic process |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| carbohydrate derivative metabolic process |
| regulation of protein localization |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| proteolysis |
| regulation of response to stress |
| response to oxygen-containing compound |
| positive regulation of cellular protein metabolic process |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Thapsigargin 0.005μM R07 exp407 | -1.98 |
| Chloroquine 32μM R08 exp470 | -1.72 |
| Geldanamycin 0.01μM R05 exp235 | 1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4594
- Expression level (log2 read counts): 4.23
Expression Distribution
EDEM2 Expression in NALM6 Cells: 4.23
