EGFL7

Entrez Summary: N/A
UniProt Summary: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {ECO:0000269|PubMed:23386126, ECO:0000269|PubMed:23639441}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

EGF CA
EMI

negative regulation of Notch signaling pathway
vasculogenesis
positive regulation of endothelial cell proliferation
regulation of Notch signaling pathway
regulation of endothelial cell proliferation
positive regulation of epithelial cell proliferation
angiogenesis
regulation of epithelial cell proliferation
signaling receptor binding
collagen-containing extracellular matrix
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
cell surface
tube morphogenesis
calcium ion binding
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
positive regulation of cell population proliferation
cell adhesion
biological adhesion
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
extracellular space
regulation of cell population proliferation
negative regulation of response to stimulus
extracellular region