ERCC4

Gene Information

Official Symbol: ERCC4
Official Name: ERCC excision repair 4, endonuclease catalytic subunit
Aliases and Previous Symbols: N/A
Entrez ID: 2072
UniProt: Q92889
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009].
UniProt Summary: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. {ECO:0000269|PubMed:19596235}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Diepoxybutane 3μM R07 exp354	-2.32
UM131593 0.1μM R01 exp58	-1.89
Apcin 50 to 100μM on day4 R04 exp176	-1.87
BN82002 4μM R07 exp340	-1.86
Senexin-A 25μM R07 exp400	-1.8
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.8
I-BRD9 4μM R07 exp365	-1.79

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1543
Expression level (log2 read counts): 4.87

Expression Distribution

regulation of double-stranded telomeric DNA binding
negative regulation of double-stranded telomeric DNA binding
nucleotide-excision repair involved in interstrand cross-link repair
negative regulation of telomeric DNA binding
regulation of protection from non-homologous end joining at telomere
negative regulation of protection from non-homologous end joining at telomere
telomeric DNA-containing double minutes formation
3 overhang single-stranded DNA endodeoxyribonuclease activity
nucleotide-excision repair factor 1 complex
regulation of telomere maintenance in response to DNA damage
negative regulation of telomere maintenance in response to DNA damage
ERCC4-ERCC1 complex
regulation of telomeric DNA binding
telomerase inhibitor activity
nucleotide-excision repair complex
negative regulation of telomere capping
endodeoxyribonuclease activity
single-stranded DNA endodeoxyribonuclease activity
TFIID-class transcription factor complex binding
negative regulation of telomerase activity
telomere maintenance via recombination
UV protection
mitotic recombination
resolution of meiotic recombination intermediates
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3-to lesion
meiotic chromosome separation
global genome nucleotide-excision repair
negative regulation of telomere maintenance via telomere lengthening
regulation of telomere capping
chromosome separation
negative regulation of telomere maintenance
nucleotide-excision repair, DNA incision, 5-to lesion
transcription factor TFIID complex
negative regulation of DNA biosynthetic process
nucleotide-excision repair, DNA incision
chromosome, telomeric region
reciprocal meiotic recombination
regulation of telomerase activity
interstrand cross-link repair