ERO1L

Entrez Summary: N/A
UniProt Summary: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
35°C R06 exp302	-1.71
FTY720 3μM R08 exp483	1.98

animal organ senescence
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
protein maturation by protein folding
4-hydroxyproline metabolic process
protein folding in endoplasmic reticulum
protein disulfide isomerase activity
protein disulfide oxidoreductase activity
brown fat cell differentiation
chaperone cofactor-dependent protein refolding
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
de novo posttranslational protein folding
de novo protein folding
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
chaperone-mediated protein folding
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
cell redox homeostasis
cytosolic calcium ion transport
endoplasmic reticulum unfolded protein response
fat cell differentiation
oxidoreductase activity
regulation of sequestering of calcium ion
cellular response to unfolded protein
cellular response to topologically incorrect protein
intrinsic apoptotic signaling pathway
response to unfolded protein
response to temperature stimulus
response to topologically incorrect protein
cellular response to hypoxia
calcium ion transmembrane transport
cellular modified amino acid metabolic process
cellular response to decreased oxygen levels
alpha-amino acid metabolic process
cellular response to oxygen levels
protein maturation
protein folding
cellular response to oxidative stress
calcium ion transport
response to endoplasmic reticulum stress