ESM1

Entrez Summary: N/A
UniProt Summary: Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. {ECO:0000269|PubMed:20616313}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of hepatocyte growth factor receptor signaling pathway
hepatocyte growth factor receptor binding
regulation of hepatocyte growth factor receptor signaling pathway
insulin-like growth factor binding
sprouting angiogenesis
integrin binding
angiogenesis
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
positive regulation of cell population proliferation
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
extracellular region