FAAH

Entrez Summary: This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008].
UniProt Summary: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269|PubMed:17015445}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anandamide amidohydrolase activity
oleamide hydrolase activity
amidase activity
fatty acid amide hydrolase activity
monoacylglycerol catabolic process
monoacylglycerol metabolic process
acylglycerol lipase activity
organelle membrane
acylglycerol catabolic process
neutral lipid catabolic process
glycerolipid catabolic process
arachidonic acid metabolic process
fatty acid catabolic process
acylglycerol metabolic process
neutral lipid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
fatty acid derivative metabolic process
cellular lipid catabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
cytoskeleton
glycerolipid metabolic process
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process