FAM126A

Entrez Summary: The protein encoded by this gene may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC). [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinorelbine 0.001μM R05 exp249	-1.94
DABN racemic mixture R03 exp93	1.7
Sucrose 20000μM R06 exp298	1.73
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.85
Nocodazole 0.2μM R02 exp64	1.95
SB743921 0.001μM R05 exp244	2.02
Vinblastine 0.015μM R05 exp208	2.34
Nocodazole 0.2μM R00 exp24	2.6
Rotenone 2μM R00 exp33	2.69

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol phosphorylation
lipid phosphorylation
myelination
axon ensheathment
ensheathment of neurons
phosphatidylinositol metabolic process
protein localization to plasma membrane
lipid modification
protein localization to cell periphery
glycerophospholipid metabolic process
neuron projection
phospholipid metabolic process
glycerolipid metabolic process
protein localization to membrane
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
phosphorylation
cellular protein localization
cellular macromolecule localization