FANCB

Entrez Summary: This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016].
UniProt Summary: DNA repair protein required for FANCD2 ubiquitination. {ECO:0000269|PubMed:15502827}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Diepoxybutane 3μM R07 exp354	-2.62
BML-284 0.09μM R08 exp460	-1.94

replication-born double-strand break repair via sister chromatid exchange
positive regulation of double-strand break repair via homologous recombination
Fanconi anaemia nuclear complex
negative regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair
positive regulation of double-strand break repair
negative regulation of DNA repair
positive regulation of DNA recombination
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
interstrand cross-link repair
positive regulation of DNA repair
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
double-strand break repair via homologous recombination
recombinational repair
positive regulation of response to DNA damage stimulus
regulation of DNA recombination
negative regulation of DNA metabolic process
regulation of DNA repair
double-strand break repair
positive regulation of DNA metabolic process
regulation of response to DNA damage stimulus
DNA recombination
regulation of DNA metabolic process
DNA repair
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
negative regulation of response to stimulus
cellular response to stress
positive regulation of nucleobase-containing compound metabolic process