FBXL7

Gene Information

Official Symbol: FBXL7
Official Name: F-box and leucine rich repeat protein 7
Aliases and Previous Symbols: N/A
Entrez ID: 23194
UniProt: Q9UJT9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7355
Expression level (log2 read counts): -5.6

Expression Distribution

F-box-like
F-box

SCF complex assembly
SCF ubiquitin ligase complex
negative regulation of G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
negative regulation of cell cycle G2/M phase transition
ubiquitin ligase complex
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
ubiquitin-protein transferase activity
mitotic cell cycle phase transition
cell cycle phase transition
protein polyubiquitination
negative regulation of mitotic cell cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle process
proteasomal protein catabolic process
post-translational protein modification
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
centrosome
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
cell population proliferation
negative regulation of cell cycle
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cellular protein catabolic process
regulation of mitotic cell cycle
protein catabolic process
mitotic cell cycle
protein ubiquitination
regulation of cell cycle process
protein modification by small protein conjugation
cellular macromolecule catabolic process