FSTL3

Gene Information

Official Symbol: FSTL3
Official Name: follistatin like 3
Aliases and Previous Symbols: N/A
Entrez ID: 10272
UniProt: O95633
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10917
Expression level (log2 read counts): 2.15

Expression Distribution

Kazal 1
FOLN
Kazal 2

negative regulation of activin receptor signaling pathway
activin binding
neuron projection terminus
regulation of activin receptor signaling pathway
adrenal gland development
negative regulation of osteoclast differentiation
fibronectin binding
negative regulation of myeloid leukocyte differentiation
negative regulation of BMP signaling pathway
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
secretory granule
hematopoietic progenitor cell differentiation
regulation of BMP signaling pathway
negative regulation of leukocyte differentiation
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of myeloid leukocyte differentiation
endocrine system development
male gonad development
development of primary male sexual characteristics
negative regulation of hemopoiesis
negative regulation of cellular response to growth factor stimulus
male sex differentiation
lung development
respiratory tube development
cellular response to metal ion
respiratory system development
gonad development
development of primary sexual characteristics
cellular response to inorganic substance
regulation of myeloid cell differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of cell-cell adhesion
ossification
sex differentiation
kidney development
regulation of cellular response to growth factor stimulus
regulation of leukocyte differentiation
renal system development
endoplasmic reticulum lumen