FUT2
Gene Information
- Official Symbol: FUT2
- Official Name: fucosyltransferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2524
- UniProt: Q10981
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record represents the SE*01.01.01 allele.
- UniProt Summary: Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). {ECO:0000269|PubMed:21625510, ECO:0000269|PubMed:22068912, ECO:0000269|PubMed:24733310, ECO:0000269|PubMed:7876235, ECO:0000269|PubMed:8018146}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13963
- Expression level (log2 read counts): 2.77
FUT2 Expression in NALM6 Cells: 2.77
